Anoikis-related diagnostic markers in chronic thromboembolic pulmonary hypertension were analyzed. The pathogenesis of Anoikis has not been clearly studied in CTEPH, and clinical diagnostic markers related to Anoikis are lacking. Therefore, in this study, diagnostic markers related to Anoikis were studied using R based on GEO database and verified by transcriptomics. This study provides new findings for basic research and new diagnostic indicators for clinical diagnosis.