The data refers to ultrasonic guided wave (GW) measurements on a full-scale composite torsion box stiffened panel subjected to realistic high-amplitude low-frequency vibrations (LFV) audible machinery sound waves (SW). The purpose of the study was to gain knowledge about the effects of structural LFV and machinery SW on ultrasonic GW propagation. The data in this dataset was collected in the Netherlands Aerospace Centre – NLR, located in Marknesse, the Netherlands