This dataset contains all data and analysis scripts pertaining to the research conducted for the JMIR paper: “Technological State of the Art of E-mental Health Interventions for Major Depressive Disorder: A Systematic Literature Review.” In the scope of the research conducted and described in this paper, we have developed a relational database to systematically describe e-mental health systems for the prevention and treatment of Major Depressive Disorder (MDD). For the purpose of creating this database, literature had to be retrieved from PubMed, Scopus, and Web of Knowledge and filtered for inclusion and exclusion based on title, abstract, and full-paper. Samples of records at each stage were double coded. Once the final body of literature was identified, information from the papers had to be extracted (coded) and entered into the database. Four of the database attributes were selected to be double coded again on samples. Furthermore, a set of scales was