This work aimed at investigating the presence of disseminated neoplasia in the Baltic clam Limecola balthica. We conducted a field survey in the Dutch Wadden Sea (10 sampling sites) to determine the prevalence of the disease in Baltic tellins in the Wadden Sea and to quantify its severity via histology. Briefly, bivalves were sampled by brushing away the first 10 cm of the sediment surface. Organisms were then collected by hand and keep in the Davidson’s fixative on back in the lab. Tissues of samples were then collected and embedded in paraffin blocks. Histological sections of 5 µm thickness were stained with haematoxylin and eosin (H&E), and the slides examined for the presence of disseminated neoplasia using light microscopy. If neoplastic cells were present, we determined the disease severity according to Christensen et al. (1974) and Pekkarinen (1993) as follows: stage 1, local neoplastic cells noticed in the gills; stage